Medical University in Lublin, Poland
Title: Serum Î²-endorphin and cortisol changes in children with simple obesity
Robert Piekarski has his experience in clinical and experimental endocrinology with the special interest for diabetes mellitus. He combines scientific and didactic activities with work with patients. Present position is Senior Assistant in Department of Pediatric Endocrinology and Diabetology, Medical University of Lublin, Poland and Children’s University Hospital in Lublin. The present research activities focused on type 1 diabetes with the special interest for aspects concerning the prevention and the possibility of residual pancreatic beta cells protection on the onset of diabetes (e.g. the role of vitamin D3).
Statement of the Problem The results of experimental examinations concerning simple obesity suggest hypothalemic control disturbances of pituitary β-endorphin (β-E) and ACTH secretion. It is known that β-E take part in food intake stimulation through hunger and satiety centers control and the human endogenous opioid system is linked with variety of mood and hedonic functions. Although hyperendorphinaemia in obesity is well documented, it is unclear whether altered ß-endorphin secretion and metabolism is directly involved in the pathogenesis of obesity or only a consequence of obesity. Patients and methods Morning plasma β-E (ρmol/L) (RIA Kit Incstar corp.) and cortisol (nmol/L) (FPIA Abbott) levels in 30 children (10-16 year old) with simple obesity (body mass >95 c, mean BMI=29) and 30 healthy pears were determined before and after lasting treatment (diet of 1000 kcal) when 10% body mass reduction was obtained. Findings In healthy children mean β-E levels were 8,43 ± 1,4. In children with obesity β-E levels (M=12,87±2,3) were increased (p<0,01). And next have been decreasing (p<0,001) to 6,32 ± 1,2 at the same time with body mass reduction. The cortisol levels in healthy children were 480,24±57,9. In children with obesity the cortisol levels were higher (p<0,01) M=686,41±71,7. At the same time during body mass reduction the cortisol levels (M= 400,77 ± 50,6) were decreased (p<0,01). Normalizing tendencies of β-E and cortisol levels with body mass reduction concerned over 80% of children. Conclusion In children with simple obesity β-E and cortisol levels were higher than in healthy children. β-E and cortisol levels tend to normalize at the same time with body mass reduction. It seems that treatment with an endorphin blockers drugs may have an additional beneficial role in the treatment of people with obesity.